Table 3. Pharmacokinetic parameters of ZB716 orally administered to rats at 10 mg/kg based on a noncompartment extravascular model.

PK Parameter	Value	Unit
Lambda_z	0.04	1/h
t1/2	17.03	h
Tmax	2	h
Cmax	158.12	ng/mL
Clast_obs/Cmax	0.04
AUC 0-t	1300.99	ng/mL*h
AUC 0-inf_obs	1451.82	ng/mL*h
AUC 0-t/0-inf_obs	0.90
MRT 0-inf_obs	18.44	h
Vz/Fobs	13.97	(mg/kg)/(ng/mL)
Cl/Fobs	0.57	(mg/kg)/(ng/mL)/h

Note: C_{last obs} means the last observed concentration; Cl/F_obs means apparent total clearance of the drug from plasma after oral administration; V_z/F_obs means apparent volume of distribution during terminal phase after non-intravenous administration; MRT_{0-inf_obs} means the observed mean residence time from 0→∞; Lambda_z means terminal rate constant.