. 2017 Oct 17;8(61):103919–103930. doi: 10.18632/oncotarget.21865

Table 1. The top five miRNAs according to MNBO score.

miRNA	MNBO Score¹	Major Target²
MIR-145	-5914.13	MDM2
MIR-495	-4967.78	ELAVL1
MIR-199A-5P	-4621.1	BRCA1
MIR-21	3709.772	EEF1A1
MIR-590-3P	-3466.2	EED

1. Positive MNBO score indicates the miRNA is up-regulated in HCC, while a negative one reveals the miRNA is down-regulated. The miRNA with a bigger absolute value of MNBO score is supposed to be more important than the miRNA with a smaller absolute value of MNBO score.

2. Major target is the target that has the largest network influence among all the targets of one miRNA.