Table 1. The top five miRNAs according to MNBO score.
miRNA | MNBO Score1 | Major Target2 |
---|---|---|
MIR-145 | -5914.13 | MDM2 |
MIR-495 | -4967.78 | ELAVL1 |
MIR-199A-5P | -4621.1 | BRCA1 |
MIR-21 | 3709.772 | EEF1A1 |
MIR-590-3P | -3466.2 | EED |
1. Positive MNBO score indicates the miRNA is up-regulated in HCC, while a negative one reveals the miRNA is down-regulated. The miRNA with a bigger absolute value of MNBO score is supposed to be more important than the miRNA with a smaller absolute value of MNBO score.
2. Major target is the target that has the largest network influence among all the targets of one miRNA.