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. 2017 Oct 17;8(61):103919–103930. doi: 10.18632/oncotarget.21865

Table 1. The top five miRNAs according to MNBO score.

miRNA MNBO Score1 Major Target2
MIR-145 -5914.13 MDM2
MIR-495 -4967.78 ELAVL1
MIR-199A-5P -4621.1 BRCA1
MIR-21 3709.772 EEF1A1
MIR-590-3P -3466.2 EED

1. Positive MNBO score indicates the miRNA is up-regulated in HCC, while a negative one reveals the miRNA is down-regulated. The miRNA with a bigger absolute value of MNBO score is supposed to be more important than the miRNA with a smaller absolute value of MNBO score.

2. Major target is the target that has the largest network influence among all the targets of one miRNA.