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. 2017 Oct 24;8(61):104136–104148. doi: 10.18632/oncotarget.22024

Figure 6. N-acetylcysteine prevents oxidative stress and DNA oxidative damage.

Figure 6

A cohort of animals treated for 7 days received 80 mmol/L N–acetyl–L-cysteine (NAC) in drinking water ad libitum. (A) Reactive oxygen species content in liver tissue were determined by dihydroethidium (DHE, 5 μM, in red) and 2’,7’ –dichlorofluorescin diacetate (DCFDA, 5 μM, in green). Representative images obtained by confocal microscopy. Original magnification X100. (B) Serum aspartate aminotransferase (AST) activity, (C) 8-oxodeoxiGuanine (8-oxodG) content determined by HPLC. Each column represents the mean ± SEM in at least four different mice. *, p ≤ 0.05 vs Chow control animals; &, p ≤ 0.05 vs DEN treated Chow.