. 2017 Nov 1;8(61):104330–104346. doi: 10.18632/oncotarget.22236

Table 1. P values for multivariate analyses of associations between clinicopathological data and expression of quantile-normalized CEACAM1, CEACAM5, CEACAM6 and EPHA2 genes*.

Stages		CEACAM1		CEACAM5		CEACAM6		EPHA2
Stages		T3-T4	T1-T4	T3-T4	T1-T4	T3-T4	T1-T4	T3-T4	T1-T4
Age	≥60	0.227	0.247	0.138	0.282	0.205	0.455	0.893	0.688
	< 60	0.524	0.297	0.294	*0.059*	0.976	0.553	0.226	0.320
Gender	M	*0.078*	*0.056*	0.693	0.449	0.820	0.895	0.723	0.865
	F	0.517	0.674	0.359	0.920	*0.018*	*0.092*	0.484	0.304
Primary tumor site	SC	0.568	0.240	*0.036*	*0.010*	0.357	*0.049*	*0.049*	*0.013*
	R	0.201	0.133	0.704	0.659	0.438	0.319	0.208	0.271
Primary lymphatic presentation	≥ 60	*0.013*	*0.015*	*5×10*^-5	*6×10*^-5	0.233	0.202	*0.012*	*0.013*
	< 60	0.848	0.997	0.987	0.746	0.734	0.809	0.917	0.892
	M	0.348	0.381	*0.035*	*0.047*	0.262	0.268	*0.091*	*0.095*
	F	0.217	0.225	*0.076*	*0.052*	0.740	0.929	0.529	0.530
Lymphatic invasion		0.743	0.707	0.837	0.890	0.237	0.163	0.608	0.804
Venous invasion		0.782	0.256	0.786	0.299	0.436	0.210	*0.021*	*0.041*

^* P values are indicated for associations between each of the genes and the indicated covariate, either for T3-T4 stages or T1-T4 stages; statistically significant values (P < 0.1) are indicated in bold italics. ≥ 60 or < 60, greater/equal or lower than 60 years of age; M, male; F, female; SC, sigmoid colon; R, rectum. Primary lymphatic presentation: The yes/no/unknown indicator whether a lymph node assessment was performed at the primary presentation of disease.