Figure 7. Workflow of the proposed radiomics method (i.e., our pipeline, similar to [6, 7]).

(1) Acquisition of pre-treatment lung CT images; (2) Gross tumor volume segmentation and NSCLC subtype labelling; (3) Extraction of 24 texture and shape features from gross tumor volumes; (4) Feature significance analysis based on Spearman rank correlation, Kaplan-Meier estimator and log-rank test, and multivariate prediction of survival using random forests.