Table 1. Gene ontology analysis of differentially expressed genes associated with CRC.
| Expression | Category | Term | Description | Gene count | P value |
|---|---|---|---|---|---|
| Up-regulated | GOTERM_BP_DIRECT | GO:0030199 | collagen fibril organization | 5 | 3.77E-06 |
| GOTERM_BP_DIRECT | GO:0071230 | cellular response to amino acid stimulus | 4 | 4.37E-04 | |
| GOTERM_BP_DIRECT | GO:0071711 | basement membrane organization | 2 | 0.02585 | |
| GOTERM_BP_DIRECT | GO:0043589 | skin morphogenesis | 2 | 0.02585 | |
| GOTERM_BP_DIRECT | GO:0070208 | protein heterotrimerization | 2 | 0.029489 | |
| GOTERM_CC_DIRECT | GO:0005615 | extracellular space | 12 | 2.06E-05 | |
| GOTERM_CC_DIRECT | GO:0005578 | proteinaceous extracellular matrix | 5 | 0.001402 | |
| GOTERM_CC_DIRECT | GO:0005584 | collagen type I trimer | 2 | 0.006026 | |
| GOTERM_CC_DIRECT | GO:0005581 | collagen trimer | 3 | 0.00709 | |
| GOTERM_CC_DIRECT | GO:0070062 | extracellular exosome | 13 | 0.018026 | |
| GOTERM_MF_DIRECT | GO:0005201 | extracellular matrix structural constituent | 4 | 2.14E-04 | |
| GOTERM_MF_DIRECT | GO:0050840 | extracellular matrix binding | 2 | 0.070803 | |
| Down-regulated | GOTERM_BP_DIRECT | GO:0006805 | xenobiotic metabolic process | 6 | 1.22E-04 |
| GOTERM_BP_DIRECT | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 4 | 1.76E-04 | |
| GOTERM_BP_DIRECT | GO:0055114 | oxidation-reduction process | 12 | 0.001093 | |
| GOTERM_BP_DIRECT | GO:0006654 | phosphatidic acid biosynthetic process | 4 | 0.001308 | |
| GOTERM_BP_DIRECT | GO:0006635 | fatty acid beta-oxidation | 4 | 0.002542 | |
| GOTERM_CC_DIRECT | GO:0070062 | extracellular exosome | 35 | 4.89E-05 | |
| GOTERM_CC_DIRECT | GO:0016021 | integral component of membrane | 50 | 3.38E-04 | |
| GOTERM_CC_DIRECT | GO:0005743 | mitochondrial inner membrane | 10 | 0.0016 | |
| GOTERM_CC_DIRECT | GO:0005903 | brush border | 4 | 0.005996 | |
| GOTERM_CC_DIRECT | GO:0005829 | cytosol | 32 | 0.008631 | |
| GOTERM_MF_DIRECT | GO:0016491 | oxidoreductase activity | 9 | 3.07E-05 | |
| GOTERM_MF_DIRECT | GO:0050660 | flavin adenine dinucleotide binding | 6 | 4.39E-05 | |
| GOTERM_MF_DIRECT | GO:0009055 | electron carrier activity | 6 | 2.23E-04 | |
| GOTERM_MF_DIRECT | GO:0051015 | actin filament binding | 6 | 0.001286 | |
| GOTERM_MF_DIRECT | GO:0003995 | acyl-CoA dehydrogenase activity | 3 | 0.004184 |
If there were more than five terms enriched in this category, top five terms were selected according to P value. Count: the number of enriched genes in each term.