Table 2. KEGG pathway analysis of differentially expressed genes associated with NSCLC.
| Expression | Pathway ID | Description | Gene count | P value | Genes |
|---|---|---|---|---|---|
| Up-regulated | 04974 | Protein digestion and absorption | 5 | 5.87E-05 | COL4A1, COL1A2, COL12A1, COL1A1, COL5A2 |
| 04512 | ECM-receptor interaction | 5 | 6.74E-05 | COL4A1, COL1A2, COL1A1, COL5A2, SPP1 | |
| 05146 | Amoebiasis | 5 | 1.46E-04 | COL4A1, COL1A2, CXCL8, COL1A1, COL5A2 | |
| 04510 | Focal adhesion | 6 | 1.56E-04 | COL4A1, COL1A2, COL1A1, COL5A2, PARVB, SPP1 | |
| 04151 | PI3K-Akt signaling pathway | 6 | 0.001474 | COL4A1, COL1A2, COL1A1, GNG4, COL5A2, SPP1 | |
| Down-regulated | 00920 | Sulfur metabolism | 6 | 1.53E-08 | TST, SQRDL, ETHE1, CYCS, BPNT1, PAPSS2 |
| 01100 | Metabolic pathways | 27 | 1.96E-05 | ACOX1, PLD1, HSD17B2, ACADS, ENPP3, MAOA, NAT1, CYCS, NAT2, ADH1C, ADH6, GPAT3, CMBL, TST, GBA3, MTM1, PLCE1, HMGCS2, AKR1B10, PGM1, ETNK1, UGT2A3, AHCYL2, PAPSS2, BPNT1, UGP2, ACAA1 | |
| 00071 | Fatty acid degradation | 6 | 5.16E-05 | ACOX1, CPT2, ACADS, ADH1C, ADH6, ACAA1 | |
| 00500 | Starch and sucrose metabolism | 4 | 0.003544 | GBA3, ENPP3, PGM1, UGP2 | |
| 00982 | Drug metabolism - cytochrome P450 | 5 | 0.0037 | FMO5, MAOA, ADH1C, ADH6, UGT2A3 |
If there were more than five terms enriched in this category, top five terms were selected according to P value. Count: the number of enriched genes in each term.