Table 4. Univariate and multivariate analyses of prognostic factors for overall survival.

	Univariate Analysis			Multivariate Analysis
	HR	95% CI	P	HR	95% CI	P
RFA & Repeated SR	1.136	0.610–2.116	0.687	1.058	0.375–2.988	0.915
Gender	1.868	0.997–3.501	0.051	0.405	0.088–1.872	0.247
HBsAg positive	0.860	0.464–1.594	0.631	0.136	0.026–0.720	0.019
Anti-HCV-Ab positive	0.916	0.496–1.689	0.778	0.498	0.109–2.275	0.368
Liver cirrhosis	1.171	0.559–2.453	0.676	6.172	0.940–40.50	0.058
Histologic grade of initial tumor (I vs non-I)	10.04	2.209–45.64	0.003	242.4	10.12–5800.7	0.001
Microvascular invasion of initial tumor	0.842	0.353–2.005	0.697	1.572	0.399–6.193	0.518
Age at the time of tumor recurrence	1.011	0.982–1.041	0.465	1.075	1.012–1.143	0.019
Recurrent tumor size	1.002	0.604–1.662	0.994	2.532	0.932–6.875	0.068
Recurrent tumor number	1.423	0.741–2.733	0.290	0.700	0.172–2.856	0.620
AFP level at the time of tumor recurrence	1.004	1.001–1.007	0.007	1.005	1.001–1.009	0.014
Time from initial resection to 1st recurrence	0.974	0.957–0.991	0.003	0.965	0.940–0.991	0.009
Time from treatment of 1st recurrent HCC to 2nd recurrence	0.973	0.954–0.993	0.008	0.949	0.911 – 0.989	0.013