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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Mol Endocrinol. 2017 Nov 1;60(1):R1–R8. doi: 10.1530/JME-17-0151

Figure 1. Activation of insulin signaling regulates the metabolisms of glucose and lipids, and protein synthesis.

Figure 1

Phosphorylation at Y972 of the β-subunit generates a NPXpY motif, leading to the increase in the affinity of the IRS binding to the IR and the tyrosine phosphorylation of IRS.