Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Mol Endocrinol. 2017 Nov 1;60(1):R1–R8. doi: 10.1530/JME-17-0151

Figure 2. Phosphorylation of IRS at serine and threonine residues by Ser/Thr kianses impairs insulin signaling.

Figure 2

Activation of Ser/Thr kianses by hyperglycemia, lipids, inflammation, and ER stress leads to the inhibitory serine and threonine phosphorylation of IRS, causing insulin resistance. O-GlcNAc modification of IRS can affect its phosphorylation.