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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Nov 6;47:176–181. doi: 10.1016/j.conb.2017.10.010

Figure 2. Changes to morphology of adult NMJs in response to NRG1-III overexpression by motor neurons.

Figure 2

Unlike the mature NMJs of control mice, those in animals that overexpress NRG1-III show signs of remodeling. The postsynaptic AChR aggregates are no longer found in “pretzel-like” continuous gutters, but in fragmented islands that are innervated by varicose presynaptic terminal branches. Some AChR-islands are abandoned by the motor terminal branches (arrowhead) and appear to be in the process of elimination. In addition, there is a significant increase in the number of tSCs, some of which extend long processes within and beyond the synaptic area. Scale bar: 10 μm.