Figure 5. CD8α:MyD88 T cells induce tumor regression of established melanoma tumors.

A and B) Mice bearing a established B16-F1 tumors were exposed to a sublethal dose of irradiation (550 rads) followed by transfer of 6×10⁶ pmel T cells engineered to express CD8α:MyD88 or vector control-GFP by intravenous injection one day and eight days later. Average tumor volume as well as tumor volumes for individual mice are shown. Values and error bars represent mean ± s.e.m. * p ≤ 0.05 starting on day 28 and onward. tumor growth was analyzed by a mixed model repeated measures with AR(1) covariance structure, followed by Sidak-adjusted comparisons at each time.