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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Nucl Med Biol. 2017 Sep 19;56:10–20. doi: 10.1016/j.nucmedbio.2017.09.003

Table 1.

Paired label biodistribution of [211At]SAGMB-5F7 and [131I]SGMIB-5F7 in SCID mice with subcutaneous B474M1 human breast carcinoma xenografts.

Tissue Percent injected dose per grama
1 h 2 h 4 h 21 h
211At 131I 211At 131I 211At 131I 211At 131I
Liver 3.0 ± 0.3 3.7 ± 0.4 2.4 ± 0.2 3.0 ± 0.3 2.1 ± 0.2 2.4 ± 0.4b 0.7 ± 0.1 0.5 ± 0.1
Spleen 2.5 ± 0.4 2.1 ± 0.1b 2.3 ± 0.2 1.8 ± 0.2 2.2 ± 0.3 1.8 ± 0.5b 1.0 ± 0.3 0.5 ± 0.0
Lungs 11.7 ± 0.7 14.3 ± 2.0 7.9 ± 0.8 9.7 ± 1.6 5.4 ± 1.3 5.7 ± 1.7b 1.5 ± 0.3 0.4 ± 0.2
Heart 1.8 ± 0.3 0.7 ± 0.1 1.3 ± 0.2 0.4 ± 0.0 1.1 ± 0.2 0.2 ± 0.1 0.5 ± 0.2 0.1 ± 0.0
Kidneys 85.3 ± 12.2 96.0 ± 13.6 46.2 ± 4.2 56.0 ± 3.9 23.0 ± 2.8 29.5 ± 3.4 6.1 ± 1.1 8.0 ± 1.3
Sm. Int. 1.4 ± 0.3 1.0 ± 0.2 1.1 ± 0.1 0.6 ± 0.1 0.9 ± 0.2 0.4 ± 0.1 0.6 ± 0.2 0.1 ± 0.0
Lg. Int. 0.9 ± 0.2 0.5 ± 0.1 1.1 ± 0.2 1.3 ± 0.2 0.9 ± 0.2 1.2 ± 0.2 1.1 ± 0.4 0.8 ± 0.2
Muscle 0.9 ± 0.2 0.6 ± 0.3 0.5 ± 0.2 0.3 ± 0.2 0.6 ± 0.2 0.4 ± 0.2 0.1 ± 0.0 0.0 ± 0.0
Blood 1.3 ± 0.2 1.0 ± 0.3 0.7 ± 0.1 0.3 ± 0.1 0.5 ± 0.1 0.1 ± 0.0 0.2 ± 0.1 0.0 ± 0.0
Bone 1.1 ± 0.2 0.6 ± 0.1 0.8 ± 0.2 0.4 ± 0.2 0.6 ± 0.2 0.2 ± 0.1 0.2 ± 0.1 0.1 ± 0.0
Brain 0.2 ± 0.0 0.1 ± 0.0 0.1 ± 0.0 0.0 ± 0.0 0.1 ± 0.0 0.0 ± 0.0 0.1 ± 0.0 0.0 ± 0.0
Tumor 15.7 ± 1.4 15.1 ± 1.3 15.7 ± 1.7 16.3 ± 1.9 15.5 ± 3.1 15.4 ± 3.1b 9.5 ± 1.2 11.8 ± 1.5
a

Mean ± SD (n =5).

b

Difference in uptake between the two agents statistically NOT significant.