Table 1.

Paired label biodistribution of [²¹¹At]SAGMB-5F7 and [¹³¹I]SGMIB-5F7 in SCID mice with subcutaneous B474M1 human breast carcinoma xenografts.

Tissue	Percent injected dose per grama
	1 h		2 h		4 h		21 h
	211At	131I	211At	131I	211At	131I	211At	131I
Liver	3.0 ± 0.3	3.7 ± 0.4	2.4 ± 0.2	3.0 ± 0.3	2.1 ± 0.2	2.4 ± 0.4b	0.7 ± 0.1	0.5 ± 0.1
Spleen	2.5 ± 0.4	2.1 ± 0.1b	2.3 ± 0.2	1.8 ± 0.2	2.2 ± 0.3	1.8 ± 0.5b	1.0 ± 0.3	0.5 ± 0.0
Lungs	11.7 ± 0.7	14.3 ± 2.0	7.9 ± 0.8	9.7 ± 1.6	5.4 ± 1.3	5.7 ± 1.7b	1.5 ± 0.3	0.4 ± 0.2
Heart	1.8 ± 0.3	0.7 ± 0.1	1.3 ± 0.2	0.4 ± 0.0	1.1 ± 0.2	0.2 ± 0.1	0.5 ± 0.2	0.1 ± 0.0
Kidneys	85.3 ± 12.2	96.0 ± 13.6	46.2 ± 4.2	56.0 ± 3.9	23.0 ± 2.8	29.5 ± 3.4	6.1 ± 1.1	8.0 ± 1.3
Sm. Int.	1.4 ± 0.3	1.0 ± 0.2	1.1 ± 0.1	0.6 ± 0.1	0.9 ± 0.2	0.4 ± 0.1	0.6 ± 0.2	0.1 ± 0.0
Lg. Int.	0.9 ± 0.2	0.5 ± 0.1	1.1 ± 0.2	1.3 ± 0.2	0.9 ± 0.2	1.2 ± 0.2	1.1 ± 0.4	0.8 ± 0.2
Muscle	0.9 ± 0.2	0.6 ± 0.3	0.5 ± 0.2	0.3 ± 0.2	0.6 ± 0.2	0.4 ± 0.2	0.1 ± 0.0	0.0 ± 0.0
Blood	1.3 ± 0.2	1.0 ± 0.3	0.7 ± 0.1	0.3 ± 0.1	0.5 ± 0.1	0.1 ± 0.0	0.2 ± 0.1	0.0 ± 0.0
Bone	1.1 ± 0.2	0.6 ± 0.1	0.8 ± 0.2	0.4 ± 0.2	0.6 ± 0.2	0.2 ± 0.1	0.2 ± 0.1	0.1 ± 0.0
Brain	0.2 ± 0.0	0.1 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.1 ± 0.0	0.0 ± 0.0	0.1 ± 0.0	0.0 ± 0.0
Tumor	15.7 ± 1.4	15.1 ± 1.3	15.7 ± 1.7	16.3 ± 1.9	15.5 ± 3.1	15.4 ± 3.1b	9.5 ± 1.2	11.8 ± 1.5

^aMean ± SD (n =5).

^bDifference in uptake between the two agents statistically NOT significant.