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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Nucl Med Biol. 2017 Sep 19;56:10–20. doi: 10.1016/j.nucmedbio.2017.09.003

Table 2.

Paired label biodistribution of iso-[211At]SAGMB-5F7 and iso-[131I]SGMIB-5F7 in SCID mice with subcutaneous B474M1 human breast carcinoma xenografts.

Tissue Percent injected dose per grama
1 h 2 h 4 h 21 h
211At 131I 211At 131I 211At 131I 211At 131I
Liver 2.7 ± 0.4 2.2 ± 0.4 2.2 ± 0.3 1.7 ± 0.3 1.4 ± 0.3 0.9 ± 0.2 0.6 ± 0.5 0.2 ± 0.1
Spleen 1.9 ± 0.7 1.4 ± 0.7 1.4 ± 0.3 0.9 ± 0.3 1.1 ± 0.1 0.7 ± 0.1 1.4 ± 2.2 0.1 ± 0.1b
Lungs 4.6 ± 0.5 5.2 ± 0.9b 3.7 ± 0.4 3.2 ± 0.7b 2.6 ± 0.2 2.5 ± 0.9b 2.1 ± 2.3 0.2 ± 0.1b
Heart 1.4 ± 0.2 0.7 ± 0.2 1.0 ± 0.1 0.4 ± 0.1 0.7 ± 0.1 0.2 ± 0.0 0.7 ± 1.1 0.0 ± 0.0b
Kidneys 65.5 ± 14.5 58.9 ± 15.1 37.8 ± 9.7 32.2 ± 7.0 15.8 ± 1.4 13.0 ± 1.1 3.1 ± 1.5 1.6 ± 0.4
Sm. Int. 3.0 ± 2.3 2.9 ± 2.7b 1.1 ± 0.3 0.7 ± 0.2 0.7 ± 0.1 0.3 ± 0.1 0.9 ± 1.3 0.3 ± 0.5b
Lg. Int. 1.9 ± 1.3 1.8 ± 1.4b 0.8 ± 0.1 0.6 ± 0.1 2.0 ± 0.4 1.8 ± 0.4b 2.2 ± 3.7 2.8 ± 5.3b
Muscle 0.8 ± 0.1 0.7 ± 0.2 0.4 ± 0.1 0.3 ± 0.1 0.2 ± 0.0 0.1 ± 0.0 0.2 ± 0.2 0.0 ± 0.0b
Blood 1.1 ± 0.2 0.8 ± 0.2 0.6 ± 0.1 0.3 ± 0.0 0.4 ± 0.1 0.2 ± 0.1 0.2 ± 0.2 0.0 ± 0.0
Bone 0.9 ± 0.1 0.7 ± 0.1 0.7 ± 0.1 0.5 ± 0.2 0.4 ± 0.1 0.2 ± 0.2 0.3 ± 0.3 0.0 ± 0.0b
Brain 0.2 ± 0.0 0.1 ± 0.0 0.1 ± 0.0 0.0 ± 0.0 0.1 ± 0.0 0.0 ± 0.0 0.1 ± 0.1 0.0 ± 0.0b
Tumor 21.2 ± 0.7 22.8 ± 0.9 22.5 ± 5.3 25.0 ± 6.1 23.4 ± 2.2 25.2 ± 2.4 14.6 ± 6.1 17.4 ± 6.2
a

Mean ± SD (n =5).

b

Difference in uptake between the two agents statistically NOT significant.