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. 2017 Dec 12;9:395. doi: 10.3389/fnagi.2017.00395

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Copyright © 2017 Namikawa, Sano and Tateno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of bicuculline methiodide (BMI) and CGP 55845 hydrochloride (CGP) on cortical LFP responses evoked by stimulation at one site in L4. (A) Typical examples of BMI effects on LFPs in older SAMR1 (13-month old) and SAMP1 (13-month old) mice. (top) In SAMR1, typical LFP responses in L2/3 (a1), L4 (b1) and L5 (c1) are illustrated in the control, 4-μM BMI (20 and 40 min after superfusion), and washout conditions. (bottom) Similarly, in SAMP1, typical LFP responses in L2/3 (a2), L4 (b2) and L5 (c2) are illustrated in the control, 4-μM BMI (40 min after superfusion), and washout conditions. (B) Representative examples of effects of CGP on LFPs in older SAMR1 (13-month old, top) and SAMP1 (13-month old, bottom) mice. (top) In SAMP1, typical LFP responses in L2/3 (a1), L4 (b1) and L5 (c1) are illustrated in the control, 2-μM CGP (30 min after superfusion), and washout conditions. (bottom) Similarly, typical LFP responses in L2/3 (a2), L4 (b2) and L5 (c2) are illustrated in the control, 2-μM CGP (30 min after superfusion), and washout conditions.