Figure 11.
Effects of individual and simultaneous application of SS and BMI on cortical LFP responses evoked by stimulation at one site in L4. (A) Representative example of an older SAMR1 mouse (13-month old). In (a), following 1.4 mM SS administration (T2), the superfusion of 4-μM BMI gradually decreased the negative peaks of LFP amplitudes (T3) in the three layers (L2/3, L4 and L5) compared with post-SS and control (T1). At T4 the drug had been washed out. Typical LFP responses in L2/3 (b), L4 (c) and L5 (d) in each condition are illustrated. Durations of the four (control, post-SS, SS/BMI and washout) conditions are given in the white, gray, black and white bars on the top, respectively. (B) A representative example of an older SAMP1 mouse (13-month old). As in Part (A), the time courses of peak amplitudes in the three layers are shown in (a). The waveforms at the four time points (T1, T2, T3, and T4) in the three layers (b–d) are illustrated under the four conditions.