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. 2017 Dec 12;9:395. doi: 10.3389/fnagi.2017.00395

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Copyright © 2017 Namikawa, Sano and Tateno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of sodium salicylate (SS) on cortical LFPs evoked by stimulation at one site in L4. (A) Representative example of an older SAMR1 mouse (13-month old). In (a), superfusion of 1.4-mM SS decreased negative peak LFP amplitudes (T₂) in the three layers, compared with control (T₁) or after the drug was washed out (T₃). The durations of the three (pre-SS, post-SS and washout) conditions are given in the back and white bars on the top of the panel. Typical LFP responses observed in L2/3 (b), L4 (c) and L5 (d) at the three time points (T₁, T₂ and T₃) are illustrated. (B) Similarly, a representative example of an older SAMP1 mouse (13-month old). In (a), superfusion of 1.4 mM SS also decreased negative peak LFP amplitudes (T₂) compared with control (T₁) or after the drug was washed out (T₃). Typical LFP responses observed in L2/3 (b), L4 (c) and L5 (d) at the three time points (T₁, T₂ and T₃) are illustrated.