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. 2017 Dec 12;9:395. doi: 10.3389/fnagi.2017.00395

Figure 6.

Figure 6

Effects of muscimol (MSC) on cortical LFP responses evoked by stimulation at one site in L4. (A) A representative example of an older SAMR1 mouse (12.5-month old). In (a), superfusion of 5-μM MSC decreased the negative peak amplitudes of LFPs (T2 and T3) in the three layers (L2/3, L4 and L5), compared with control (T1). At T4, the drug had been washed out. Durations of the three (control, 5-μM MSC, and washout) conditions are given in the black and white bars on the top. Typical LFP responses in L2/3 (b), L4 (c) and L5 (d) at the four time points (T1, T2, T3 and T4) are illustrated. (B) Similarly, a representative example of an older SAMP1 mouse (13-month old). In (a), superfusion of 5-μM MSC also decreased the negative peak amplitudes of LFPs (T2 and T3), compared with control (T1). At T4, the drug had been washed out. Typical LFP responses in L2/3 (b), L4 (c) and L5 (d) at the four time points (T1, T2, T3 and T4) are illustrated.