Table 2.

Meta-analysis results of the associations between APOE ε2/ε3/ε4 polymorphisms and risk of coronary artery diseases in type 2 diabetes patients.

Genetic model	Pooled OR (95%CI)	Z-value	Pmeta−analysis	NO. of studies	Modela	Pheterogeneityb	I2%
ε2/ε2 vs. ε3/ε3	1.67(0.90–3.09)	1.62	0.104	9	F	0.532	0.00
Chinese	2.03(0.98–4.21)	0.02	0.984	4	F	0.841	0.00
Non-Chinese	1.01(0.31–3.32)	1.90	0.058	5	F	0.208	32.00
ε2/ε3 vs. ε3/ε3	1.18(0.93–1.51)	1.36	0.175	12	F	0.151	30.10
Chinese	1.21(0.76–1.95)	0.80	0.423	6	F	0.450	0.00
Non-Chinese	1.32(0.72–2.42)	0.89	0.374	6	R	0.053	54.30
ε2/ε4 vs. ε3/ε3	1.20(0.78–1.84)	0.83	0.405	10	F	0.493	0.00
Chinese	2.17(1.10–4.28)	2.22	0.026	5	F	0.852	0.00
Non-Chinese	0.79(0.44–1.41)	0.79	0.428	5	F	0.746	0.00
ε3/ε4 vs. ε3/ε3	1.69(1.38–2.08)	4.99	<0.001	11	F	0.312	13.90
Chinese	2.22(1.59–3.09)	4.71	<0.001	6	F	0.954	0.00
Non-Chinese	1.42(1.09–1.85)	2.57	0.010	5	F	0.186	35.30
ε4/ε4 vs. ε3/ε3	2.72(1.61–4.60)	3.72	<0.001	9	F	0.807	0.00
Chinese	4.26(1.16–15.61)	2.18	0.029	5	F	0.980	0.00
Non-Chinese	2.45(1.37–4.37)	3.03	0.002	4	F	0.291	19.70
ε2/ε2+ε2/ε3 vs. ε3/ε3	1.26(0.88–1.82)	1.25	0.212	13	R	0.071	39.50
Chinese	1.08(0.71–1.65)	0.34	0.734	7	F	0.538	0.00
Non-Chinese	1.52(0.81–2.85)	1.30	0.193	6	R	0.012	66.00
ε4/ε4+ε3/ε4 vs. ε3/ε3	1.83(1.52–2.22)	6.24	<0.001	13	F	0.384	6.20
Chinese	2.44(1.78–3.36)	5.51	<0.001	7	F	0.890	0.00
Non-Chinese	1.55(1.22–1.97)	3.60	<0.001	6	F	0.360	8.80
ε2 allele vs. ε3 allele	1.34(0.98–1.84)	1.81	0.070	11	R	0.054	44.70
Chinese	1.19(0.84–1.69)	0.99	0.324	6	F	0.536	0.00
Non-Chinese	1.67(0.93–3.03)	1.71	0.088	5	R	0.007	71.50
ε4 allele vs. ε3 allele	1.64(1.40–1.94)	5.97	<0.001	11	F	0.284	16.80
Chinese	2.08(1.58–2.74)	5.21	<0.001	6	F	0.987	0.00
Non-Chinese	1.44(1.17–1.77)	3.50	<0.001	5	F	0.138	42.60

OR, odd ratio; CI, confidence interval.

^aF: fixed random effect model; R: random effect model.

^bP_{heterogeneity} value for between-study heterogeneity based on Cochran's Q test.