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Pretreatment with H1 receptor antagonist pyrilamine abolishes SG-2 or T1AM-induced hyperalgesia. The nociceptive threshold of mice pre-treated (s.c.) with the H1 receptor antagonist pyrilamine (10 mg kg-1) was determined by the hot plate test 15 min after SG-2 or T1AM i.p. injection (11 μg kg-1) (n = 10 in each group). Results are expressed as means ± SEM; ∗∗P < 0.01 versus vehicle without pyrilamine (Control, left panel).
