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. 2017 Dec 12;9:410. doi: 10.3389/fnagi.2017.00410

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Copyright © 2017 Winner, Zhang, Farthing, Karchalla, Lookingland and Goudreau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations and DOPAC/DA ratio in striatum (ST) (A,C,E) and nucleus accumbens (NAc) (B,D,F) in Young, Mature, Old and Aged mice. Young, Mature, Old and Aged mice were decapitated, brains were sectioned, and ST and NAc were collected in tissue buffer for high pressure liquid chromatography coupled with electrochemical detection (HPLC-ED) analysis. DA and DOPAC were measured and normalized to mg protein per sample. Concentrations for DOPAC were divided by DA to give the DOPAC/DA ratio. Data is expressed as mean + SEM. Data was analyzed via one-way ANOVA with post hoc Holm-Sidak test. Hash symbol (#) indicates statistically significant difference (p < 0.05) from Young age group.