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. 2017 Dec 12;9:410. doi: 10.3389/fnagi.2017.00410

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Copyright © 2017 Winner, Zhang, Farthing, Karchalla, Lookingland and Goudreau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Homovanillic acid (HVA) and 3-methoxytyramine (3-MT) concentrations after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Young and Aged ST (A,C) and NAc (B,D). Young and aged mice were treated with vehicle (VH) or 20 mg/kg MPTP and sacrificed 24 h later. Brains were sectioned and ST and NAc were collected in tissue buffer for HPLC-ED analysis. HVA and 3-MT were measured and normalized to mg protein per sample. Data is expressed as mean + SEM. Data was analyzed via two way ANOVA with post hoc Holm-Sidak test. Asterisk (*) indicates statistically significant difference (p < 0.05) from VH control, while hash symbol (#) represents statistically significant difference from Young VH.