Table 2.
KEGG pathway enrichment analysis of the genes common to GWASdb AD genes and the P. gingivalis interactome.
| KEGG pathway | p-value | q-value | Overlapping genes |
|---|---|---|---|
| BARRIER RELATED | |||
| Focal adhesion | 0.0001 | 0.006 | ACTN1; PTK2; PDGFD; PRKCA; ITGA1; ITGA4; MYLK; AKT3; MAPK10; COL4A2; COL4A1; ACTB; BCAR1; EGF |
| Protein digestion and absorption | 0.0002 | 0.006 | COL18A1; COL14A1; COL5A2; SLC8A1; COL27A1; COL4A2; COL4A1; MME; DPP4 |
| Vascular smooth muscle contraction | 0.001 | 0.019 | GNAS; PRKCA; PRKCE; RAMP1; MYLK; KCNMA1; PRKG1; ITPR3; CALD1 |
| Leukocyte transendothelial migration | 0.004 | 0.03 | ACTN1; PTK2; PRKCA; ITGA4; RASSF5; PTK2B; ACTB; BCAR1 |
| Adherens junction | 0.005 | 0.03 | TGFBR2; ACTN1; SMAD3; PTPRB; PTPN1; ACTB |
| Gap junction | 0.013 | 0.07 | PDGFD; GNAS; PRKCA; PRKG1; ITPR3; EGF |
| Regulation of actin cytoskeleton | 0.02 | 0.08 | ACTN1; PTK2; PDGFD; CYFIP2; ITGA1; ITGA4; MYLK; ACTB; BCAR1; EGF |
| DISEASES | |||
| Arrhythmogenic right ventricular cardiomyopathy | 0.0001 | 0.006 | ACTN1; ITGA1; CACNB1; SGCD; ITGA4; SLC8A1; LMNA; ACTB |
| Pathways in cancer | 0.0002 | 0.006 | TGFBR2; NOS2; PTK2; AXIN1; GNAS; MECOM; RASSF5; SMAD3; CSF1R; CYCS; PRKCA; GLI2; PPARG; AKT3; GNG2; COL4A2; COL4A1; GNB4; MAPK10; EPAS1; EGF |
| Dilated cardiomyopathy | 0.0008 | 0.013 | GNAS; ITGA1; CACNB1; SGCD; ITGA4; SLC8A1; ACTB; LMNA |
| Hypertrophic cardiomyopathy | 0.002 | 0.023 | ITGA1; CACNB1; SGCD; ITGA4; SLC8A1; LMNA; ACTB |
| Colorectal cancer | 0.002 | 0.023 | TGFBR2; AXIN1; CYCS; SMAD3; AKT3; MAPK10 |
| Non-small cell lung cancer | 0.008 | 0.04 | PRKCA; FOXO3; AKT3; RASSF5; EGF |
| Small cell lung cancer | 0.011 | 0.06 | NOS2; PTK2; CYCS; AKT3; COL4A2; COL4A1 |
| Pancreatic cancer | 0.015 | 0.07 | TGFBR2; AKT3; MAPK10; EGF; SMAD3 |
| Endometrial cancer | 0.03 | 0.09 | FOXO3; AKT3; EGF; AXIN1 |
| Insulin resistance | 0.03 | 0.1 | PPP1R3B; PRKCE; AKT3; MAPK10; PTPN1; CREB3L1 |
| Alzheimer's disease | 0.04 | 0.11 | APOE; ATP2A3; CYCS; GRIN2A; MAPT; SNCA; MME; ITPR3 |
| Transcriptional misregulation in cancer | 0.045 | 0.12 | TGFBR2; PTK2; CSF1R; HMGA2; AFF1; CD86; PPARG; MEIS1 |
| IMMUNE | |||
| AGE-RAGE signaling pathway in diabetic complications | 0.0003 | 0.008 | TGFBR2; PRKCA; PRKCE; SMAD3; AKT3; JAK2; COL4A2; COL4A1; MAPK10 |
| Hematopoietic cell lineage | 0.005 | 0.033 | CR1; CSF1R; ITGA1; CD33; ITGA4; IL6R; MME |
| Inflammatory mediator regulation of TRP channels | 0.02 | 0.09 | GNAS; CAMK2D; PRKCE; PRKCA; MAPK10; ITPR3 |
| Th17 cell differentiation | 0.03 | 0.1 | STAT6; TGFBR2; SMAD3; JAK2; MAPK10; IL6R |
| SIGNALING | |||
| Calcium signaling pathway | 0.0002 | 0.006 | NOS2; GNAS; CAMK2D; ATP2A3; MYLK; CACNA1G; PRKCA; ADRB2; PTK2B; SLC8A1; ITPR3; ATP2B2; GRIN2A |
| PI3K-Akt signaling pathway | 0.0002 | 0.006 | PTK2; PDGFD; OSMR; GHR; CSF1R; PRKCA; ITGA1; EFNA5; ITGA4; IL6R; FOXO3; AKT3; JAK2; COL4A2; COL4A1; GNB4; GNG2; EGF; CREB3L1 |
| Circadian entrainment | 0.0003 | 0.007 | GNAS; CAMK2D; GNB4; PRKG1; CACNA1G; PRKCA; GRIN2A; GNG2; ITPR3 |
| cGMP-PKG signaling pathway | 0.001 | 0.019 | ATP2A3; PRKCE; MYLK; KCNMA1; ADRB2; AKT3; PRKG1; SLC8A1; ITPR3; ATP2B2; CREB3L1 |
| Rap1 signaling pathway | 0.003 | 0.024 | PDGFD; GNAS; PRKCA; RASSF5; EFNA5; CSF1R; AKT3; ACTB; SIPA1L2; BCAR1; EGF; GRIN2A |
| ErbB signaling pathway | 0.003 | 0.025 | PTK2; NCK2; CAMK2D; PRKCA; AKT3; MAPK10; EGF |
| Ras signaling pathway | 0.005 | 0.032 | PDGFD; PRKCA; CSF1R; EFNA5; RASSF5; PLA1A; AKT3; MAPK10; GNB4; GNG2; EGF; GRIN2A |
| Adrenergic signaling in cardiomyocytes | 0.006 | 0.033 | GNAS; CAMK2D; CACNB1; PRKCA; ADRB2; AKT3; SLC8A1; ATP2B2; CREB3L1 |
| Phospholipase D signaling pathway | 0.014 | 0.07 | PDGFD; GNAS; PRKCA; EGF; PTK2B; AKT3; GRM8; DGKI |
| GnRH signaling pathway | 0.016 | 0.07 | GNAS; CAMK2D; PRKCA; PTK2B; MAPK10; ITPR3 |
| Hippo signaling pathway | 0.02 | 0.08 | TGFBR2; AXIN1; WWC1; SMAD3; GLI2; ACTB; FRMD6; TEAD4 |
| MAPK signaling pathway | 0.03 | 0.09 | TGFBR2; MECOM; CACNB1; CACNA1G; PRKCA; AKT3; MAPK10; MAPT; RELB; DUSP16; EGF |
| HIF-1 signaling pathway | 0.03 | 0.09 | NOS2; CAMK2D; IL6R; PRKCA; AKT3; EGF |
| cAMP signaling pathway | 0.03 | 0.1 | GNAS; CAMK2D; CREB3L1; ADRB2; AKT3; MAPK10; ABCC4; ATP2B2; GRIN2A |
| NEURAL | |||
| Dopaminergic synapse | 0.0006 | 0.012 | GNAS; CAMK2D; CREB3L1; PRKCA; AKT3; GNG2; MAPK10; GNB4; ITPR3; GRIN2A |
| Axon guidance | 0.002 | 0.023 | SEMA3A; PTK2; NGEF; SEMA5A; NCK2; CAMK2D; EFNA5; PRKCA; ABLIM1; EPHA5; SEMA5B |
| Cholinergic synapse | 0.003 | 0.025 | CAMK2D; GNB4; PRKCA; GNG2; AKT3; JAK2; ITPR3; CREB3L1 |
| Glutamatergic synapse | 0.004 | 0.027 | GRM8; GNAS; PRKCA; GNB4; GRIK2; GRIN2A; GNG2; ITPR3 |
| Amphetamine addiction | 0.02 | 0.07 | CAMK2D; PRKCA; GRIN2A; CREB3L1; GNAS |
| Long-term depression | 0.04 | 0.12 | PRKCA; ITPR3; PRKG1; GNAS |
| HORMONES/SECRETION | |||
| Gastric acid secretion | 0.001 | 0.019 | GNAS; CAMK2D; MYLK; KCNK2; PRKCA; ITPR3; ACTB |
| Aldosterone synthesis and secretion | 0.002 | 0.024 | GNAS; CAMK2D; PRKCE; CACNA1G; PRKCA; CREB3L1; ITPR3 |
| Vasopressin-regulated water reabsorption | 0.003 | 0.024 | DYNC1I1; CREB3L1; GNAS; DYNC2H1; DYNC1H1 |
| Salivary secretion | 0.004 | 0.027 | GNAS; PRKCA; KCNMA1; ADRB2; PRKG1; ITPR3; ATP2B2 |
| Insulin secretion | 0.01 | 0.06 | GNAS; CAMK2D; KCNMA1; PRKCA; CREB3L1; ITPR3 |
| Pancreatic secretion | 0.02 | 0.08 | ATP2A3; PRKCA; GNAS; KCNMA1; ITPR3; ATP2B2 |
| INFECTION | |||
| Amoebiasis | 0.006 | 0.033 | ACTN1; PTK2; GNAS; PRKCA; NOS2; COL4A2; COL4A1 |
| Salmonella infection | 0.01 | 0.06 | NOS2; DYNC1I1; MAPK10; DYNC1H1; ACTB; DYNC2H1 |
| Hepatitis B | 0.016 | 0.07 | STAT6; PRKCA; CYCS; SMAD3; PTK2B; AKT3; MAPK10; CREB3L1 |
| Tuberculosis | 0.018 | 0.07 | NOS2; CR1; CAMK2D; LSP1; CYCS; AKT3; JAK2; MAPK10; PIK3C3 |
| Chagas disease (American trypanosomiasis) | 0.028 | 0.09 | TGFBR2; NOS2; GNAS; SMAD3; AKT3; MAPK10 |
| Viral myocarditis | 0.039 | 0.11 | ACTB; SGCD; CYCS; CD86 |
| OTHER | |||
| Choline metabolism in cancer | 0.02 | 0.09 | PDGFD; PRKCA; DGKI; AKT3; MAPK10; EGF |
| beta-Alanine metabolism | 0.03 | 0.1 | ALDH6A1; ALDH1A3; DPYD |
| Regulation of lipolysis in adipocytes | 0.035 | 0.1 | ADRB2; AKT3; PRKG1; GNAS |
| Osteoclast differentiation | 0.0025 | 0.02 | TGFBR2; SQSTM1; CSF1R; PPARG; AKT3; MAPK10; TNFRSF11B; TREM2; RELB |
| Apoptosis | 0.036 | 0.106164 | CASP6; CYCS; AKT3; MAPK10; ITPR3; ACTB; LMNA |
The statistical significance (p-values) and false discovery corrected P-values (q-values) as determined by the CPDB website.