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. 2017 Dec 12;8:2459. doi: 10.3389/fmicb.2017.02459

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Copyright © 2017 Pajarillo, Kim, Valeriano, Lee and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global proteome profile of IPEC-J2 cells in co-culture conditions. (A) Venn diagram of unique and shared proteins detected in IPEC-J2 cells. (B) A volcano plot of the deactivated/downregulated (left, 376) and activated/upregulated (right, 277) proteins in IPEC-J2 cells. p-values were calculated and plotted in the y-axis as –log10(p-value). Values for y-axis [–log10(p-value)] above 1.3 were considered significant. (C) Non-metric multidimensional scaling (NMDS) plot of individual IPEC-J2 proteomes showing distinct clustering of each group. Individual proteomes are separated in control (C1–C4) and co-culture (T1–T4). (D) Functional classification of LM1 proteins using Gene Ontology (GO) classification from the PANTHER database (Molecular Function, Biological Processes, and Cellular Location). The numbers of downregulated (orange) and upregulated (blue) proteins are shown.