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. 2017 Dec 12;8:2459. doi: 10.3389/fmicb.2017.02459

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Copyright © 2017 Pajarillo, Kim, Valeriano, Lee and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biomarker analysis and PPI network in the IPEC-J2 proteome. (A) LEfSe score showing the statistical significance, biological consistency, and effect-size estimation of predicted biomarkers in control and co-culture groups. (B) IPEC-J2 PPI network analysis of DEPs in the STRING database using Cytoscape version 3.0. The nodes (proteins) and edges (combined scores) are plotted. Proteins that were activated (black), upregulated (dark gray), downregulated (light gray), and deactivated (white). Co-expression values are represented by the thickness of the edges (thicker edges – high co-expression, thinner edges – low co-expression).