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. 2017 Dec 12;8:986. doi: 10.3389/fphys.2017.00986

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Copyright © 2017 Lei, Wang, Clerx, Johnstone, Hortigon-Vinagre, Zamora, Allan, Smith, Gavaghan, Mirams and Polonchuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Current-voltage relationship for I_Na (left) and I_CaL (right). The red lines represent the mean peak current measured experimentally in 35 (I_Na) and 25 cells (I_CaL), and the shaded areas show the 25th and 75th percentiles of the experimental data. The peak-current voltage relation simulated with the unaltered Paci et al. (2013) model for the same protocol is shown in blue. The orange lines show the simulated results after scaling to match the maximum current.