Figure 2.

Left: Experimentally measured outward current in cell 19 during the outward protocol. Data to the left of the vertical red was omitted to remove capacitance artifacts. Right: Simulated transmembrane current during the same protocol, as set during the optimization process for cell 19. Note that this figure includes all scaling factors set by the optimization routine (see section 2.5), including ones not included in the final tailored models (such as I_Na and I_Kr). More examples of fits are shown in Supplementary Figure S5.