Figure 4.

Left: The predicted 1 Hz steady pacing APs from the individual cell optimized models (orange), the original Paci model (dashed blue), and optical mapping measurements (black) in the control conditions. We show the median and 25th and 75th percentiles of the optical mapping (gray) and action potential models (orange). All data shown are normalized (see section 2.3). For models that exhibited strong alternans (i.e., where only every second AP showed a spike-and-dome morphology) the longer of the two APs was used. Right: A histogram of APD₉₀ in the fitted models and optical mapping control (drug free) experiments. As we might expect, there is more variation in APD in the individual-cell tailored action potential models than the electrotonically-coupled tissue measurements, but the distribution is centred appropriately.