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. Author manuscript; available in PMC: 2017 Dec 17.
Published in final edited form as: J Med Chem. 2016 May 19;59(11):5311–5323. doi: 10.1021/acs.jmedchem.6b00038

Table 3.

Targeting Properties and Biodistribution of 700 nm Emitting NIR Fluorophores for Specific Organs/Tissues at 4 h Post-Injectiona

ID targeted tissues
biodistribution
AG Pa PG SG TG LN Li Ki He Lu Sp Bo
14 +++ ++ +++ ++ ++ +++ + ++
15 +++ + +++ + + + +++ +
16 + ++ +++ + + + +++ +
17 +++ ++ +++ +++ ++ +++ + +
18 + ++ + ++ ++ ++ ++ +++ +
19 + + + ++ +++ +
20 ++ +++ +++ +++ +++ +++ +++ + ++ ++
21 + + + ++ + +++ ++
22 + + + + +++ ++ +
23 + +++ +++ +++ +++ +++ ++ +++ + ++ ++
24 + + + ++ + + +++ ++ + +
25 + + + + +++ ++ +
26 ++ +++ ++ ++ +++ ++
27 + + + ++ +++ ++
28 + + + +++ +
31 ++ +++ ++ +++ ++ ++ + +++ + + +
32 ++ ++ ++ ++ ++ +++ +++ +++
33 + + ++ ++ + +++ +++ +++ + +
36 ++ +++ +++ ++ + + ++ +++ + +
37 ++ +++ ++ ++ ++ + +++ ++
38 ++ +++ ++ ++ ++ + +++ ++
a

Abbreviations used are AG, adrenal gland; Pa, pancreas; PG, pituitary gland; TG, thyroid gland; SG, salivary gland; Li, liver; Ki, kidneys; He, heart; Lu, lungs; Sp, spleen; Bo, bone; LN, lymph node. The SBR of each organ/tissue relative to the abdominal wall was quantified and labeled as −, 1–2; +, 2–3; ++, 3–5; and +++, >5.