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. 2017 Dec 12;8:1048. doi: 10.3389/fphys.2017.01048

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Copyright © 2017 Buttler, Jordão, Fragas, Ruggeri, Ceroni and Michelini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Temporal changes of blood-brain barrier permeability within autonomic areas during 5 months' life span in sedentary spontaneously hypertensive (SHR) and normotensive rats (WKY). (A) Resting mean arterial pressure (MAP) values in SHR and WKY during 5 months' life span. n = 8 rats/subgroup. Significances (^*P < 0.05) vs. WKY. (B) Images show the capillary profile (red, Rhodamine) and FITC extravasation (green) into the brain parenchyma in the paraventricular nucleus of the hypothalamus (PVN), nucleus of the tract solitary (NTS), and rostral ventrolateral medulla (RVLM) in SHR aged 1 and 5 months. (C) Graphs compare FTIC leakage changes within the three autonomic areas of SHR and WKY groups from the 1st up to the 5th month. Values are the means of 8–12 slices, 4 rats in each subgroup. Significances (P < 0.05) ^*vs. 1st month; ^†vs. age-matched WKY; ^#vs. SHR aged 3 months.