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. 2017 Dec 12;8:1041. doi: 10.3389/fphys.2017.01041

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Copyright © 2017 Fan, Sun, Fu, Hou, Li, Yang, Fu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATX inhibits Hcy-induced cardiotoxicity in vivo. Effects of ATX or/and Hcy on the mice body weight (A) and heart weight (B) in vivo. Mice were given ATX (5 mg/kg/day) or/and Hcy (300 mg/kg/day) for 2 weeks. After administration, the mice body weight and heart weight were both examined. Effects of ATX or/and Hcy on the content of GSH-Rs (C) and MDA (D). Total protein was extracted from mice heart tissue, and the content of GSH-Rs and MDA were examined by ELISA kits. (E) IHC assay of apoptosis and angiogenesis in vivo. Heart tissue were separated and cut into 4-μm section. The expressions of active-caspase-3 and CD-34 in heart tissue were detected by IHC method. All data and images were obtained from three independent trials. Bars with different characters indicates the statistical different at P < 0.05 level.