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. 2017 Nov 13;8(12):1292–1297. doi: 10.1021/acsmedchemlett.7b00386

Table 1. Enzyme Affinity and Antiviral Activity of Key Molecules.

compound enzyme19 IC50 (pM) antiviral11 EC50 (nM)
MK-8718 700 ± 600 27 ± 7
38 12 ± 1 2.8 ± 0.4
Atazanavir 40 ± 30 12 ± 4
Darunavir 13 ± 3 7 ± 2