. 2017 Nov 28;8(12):1224–1229. doi: 10.1021/acsmedchemlett.7b00239

Table 1. Representative PknA and PknB Enzyme Inhibition (K_i): SAR of 2-Aryl-Substituted Quinazolines.

compd	R₁	R₂	PknB K_i (nM)	PknA K_i (nM)
23	CH₂CN	H	5	>4000
24	H	CH₂CN	38	ND
25	H	CN	50	>4000
26	H	CONH₂	15	>4000
27	H	CH₂OH	23	2300
28	CH₂CONH₂	H	23	1800
29	CONH₂	H	29	>4000
30	CN	H	88	>4000
22	H	H	69	>4000
31	SO₂NH₂	H	24	22
32	H	SO₂NH₂	6	<8
33			<1	<8

Table 1. Representative PknA and PknB Enzyme Inhibition (Ki): SAR of 2-Aryl-Substituted Quinazolines.