Table 3. Enzyme Inhibition and MIC (μM) of Pyrimidines against Mycobacterium tuberculosis.
| compd | PknB Ki (nM) | PknA Ki (nM) | Mtb MIC (μM) |
|---|---|---|---|
| 36 | 13 | 2900 | >100 |
| 37 | 17 | <8 | 8.3 |
| 38 | <1.3 | 9 | 6.25 |
| 46 | 4 | 18 | 4.2 |
| 47 | <1 | 12 | 3.1 |
| 48 | 4 | 18 | 4.7 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.