Table 4. Selectivity of PknB Inhibitors with Reduced Inhibition of the Mammalian Kinase CDK2.
| compd | PknB Ki (nM) | PknA Ki (nM) | CDK2 Ki (nM) | selectivity |
|---|---|---|---|---|
| 46 | 4 | 18 | 7 | 2 |
| 38 | <1.3 | 9 | 17 | >13 |
| 49 | <2 | 11 | 147 | >74 |
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