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. 2017 Oct 23;8(12):1269–1274. doi: 10.1021/acsmedchemlett.7b00355

Table 1. Cytotoxicity of Prostate Cancer Cell Lines with Tested Compoundsa.

    IC50 (μmol/L)
 
compd cell lines N2 air HCR
1 PC-3 ∼1000 ∼1000 ND
DU145 851 ± 52.9 856 ± 55.2 1
2 PC-3 6.49 ± 0.67 687 ± 32.6 106
DU145 4.14 ± 0.66 842 ± 52.5 203
3 PC-3 4.70 ± 0.01 293 ± 39.6 62
DU145 1.65 ± 0.09 372 ± 41.6 225
a

Results (mean ± SEM) are from two or more independent experiments carried out in quintuplicate. HCR: hypoxia cytotoxicity ratio; HCR = IC50(air)/IC50(N2).