Table 1. Cytotoxicity of Prostate Cancer Cell Lines with Tested Compoundsa.
IC50 (μmol/L) |
||||
---|---|---|---|---|
compd | cell lines | N2 | air | HCR |
1 | PC-3 | ∼1000 | ∼1000 | ND |
DU145 | 851 ± 52.9 | 856 ± 55.2 | 1 | |
2 | PC-3 | 6.49 ± 0.67 | 687 ± 32.6 | 106 |
DU145 | 4.14 ± 0.66 | 842 ± 52.5 | 203 | |
3 | PC-3 | 4.70 ± 0.01 | 293 ± 39.6 | 62 |
DU145 | 1.65 ± 0.09 | 372 ± 41.6 | 225 |
Results (mean ± SEM) are from two or more independent experiments carried out in quintuplicate. HCR: hypoxia cytotoxicity ratio; HCR = IC50(air)/IC50(N2).