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. 2017 Dec 13;11:605. doi: 10.3389/fnhum.2017.00605

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Copyright © 2017 Lawerman, Brandsma, Verbeek, van der Hoeven, Lunsing, Kremer and Sival.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of myopathy and myoclonus on SARA %sub-scores. The x-axis represents the EOA phenotypes (myopathic versus non-myopathic, and myoclonic versus non-myoclonic). The y-axis represents the median SARA_GAIT/POSTURE %sub-score (i.e., [SARA_GAIT/POSTURE sub-score/median total score] × 100%, A,C); and the median SARA_KINETIC %sub-score (i.e., [median SARA_KINETIC score/median total score] × 100%, B,D). Boxes represent lower quartile, median and upper quartile; whiskers represent the minimum and maximum relative %sub-score. SARA_GAIT/POSTURE, SARA gait and posture sub-score; SARA_KINETIC, SARA kinetic sub-score. Comparing the %contribution of the SARA_GAIT/POSTURE to SARA_TOTAL between myopathic versus non-myopathic subgroups, revealed a significantly higher %contribution of the SARA_GAIT/POSTURE in the myopathic subgroup (A), whereas the %contribution of the SARA_KINETIC was not significantly different between both groups (B). Comparing the %contribution of the SARA_KINETIC to SARA_TOTAL between myoclonic versus non-myoclonic subgroups, revealed a significantly higher %contribution in the myoclonic subgroup (C), whereas the %contribution of the SARA_GAIT/POSTURE revealed a significantly lower %contribution in the myoclonic subgroup (D).