Table 4.

Coefficients of interaction between follow-up time and baseline inner GCIP and temporal pRNFL thickness.

	SDMT score		EDSS score
Average pRNFL thickness (μm)
Normal	Ref.		Ref.
Reduced	−4.9	P = 0.007	0.58	P < 0.001
T-pRNFL thickness (μm)
Normal	Ref.		Ref.
Reduced	−4.1	P = 0.02	0.51	P = 0.002
Inner GCC thickness (μm)
Normal	Ref.		Ref.
Reduced	−4.5	P = 0.005	0.84	P < 0.001
Inner GCIP thickness (μm)
Normal	Ref.		Ref.
Reduced	−4.1	P = 0.01	0.87	P < 0.001

pRNFL, peripapillary retinal nerve fiber layer; T-pRNFL, temporal peripapillary retinal nerve fiber layer; GCC, ganglion cell complex (composed of macular retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer); GCIP, ganglion cell–inner plexiform layer; EDSS, Expanded Disability Status Scale; SDMT, Symbol Digit Modalities Test.

Coefficients from GEE models adjusted for multiple sclerosis subtype, sex, onset age, disease duration, baseline SDMT/EDSS score, previous history of optic neuritis, and duration of exposure to first- and second-line DMTs.