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. 2017 Dec;153(6):1647–1661.e9. doi: 10.1053/j.gastro.2017.08.034

Figure 3.

Figure 3

NK-cell mediated immune response in HBV-infected HIS-HUHEP mice. (A) Absolute numbers of total human leukocytes (hCD45+) and (B) NK cells (CD3-NKp46+) from the liver and spleen of control and HBV-infected mice. Representative FACS plots show the percent positive cells in each gate. (C) Frequency of CD69+ cells among NK cells in the liver and spleen from control (grey filled line) and HBV-infected (black open line) HIS-HUHEP mice. The percentage of positive cells from HBV-infected mice is shown. (D) Expression of CD56 and CD16 in NK cells from the liver of control or HBV-infected HIS-HUHEP mice. (E) Liver leukocytes or splenocytes were restimulated ex vivo overnight and analyzed by FACS for the expression of IFN-γ or TNF-α by NK cells. Histograms show the mean and SEM. In plots each dot represents a mouse, data obtained at 14–20 wpi. Statistical analysis in A–D: Mann Whitney U test, E: 2 way ANOVA.