TABLE 1.

miRNAs in melanomagenesis and progression

miRNA	Function	Expression of miRNA	Target	Reference
miR-211	Tumor suppressor, regulation of melanocytic pigmentation, increased or decreased invasiveness	Upregulation or downregulation	NUAKI, RUNX2, TGFBR2, BRN2, NFAT5, KCNMA1, TRPM1, MITF	Levy et al. (2010), Mazar et al. (2010), Zhou et al. (2010), Boyle et al. (2011), Xu et al. (2012), Margue et al. (2013), Bell et al. (2014)
miR-200c, miR-205	Tumor suppressor	Differential expression		Xu et al. (2012)
miR-196a	Progression and invasiveness	Downregulation	HOX-B7, bFGF, ETS-1, BMP-4, HOX-C8, Cadherin-11, Calponin-1, Osteopontin,	Braig et al. (2010), Mueller and Bosserhoff (2011)
miR-149*	Oncogenic regulator	Upregulation	GSK3α, Mcl-1	Jin et al. (2011)
miR-506-514 cluster, miR-218	Melanocyte transformation (melanomagenesis) and melanoma growth	Overexpression	MITF	Streicher et al. (2012), Guo et al. (2014)

bFGF, basic fibroblast growth factor.