TABLE 2.

miRNAs in melanoma cell cycle regulation and proliferation

miRNA	Function	Expression of miRNA	Target	Reference
miR let-7b	Cell cycle regulation and proliferation	Upregulation	CDK4, cyclin D1, cyclin D3	Schultz et al. (2008)
miR-193b	Cell cycle regulation and proliferation	Downregulation	Cyclin D1	Chen et al. (2010)
miR-206	G1 cell cycle arrest and inhibition of proliferation	Downregulation	CDK4, cyclin D1, cyclin C	Georgantas et al. (2014)
miR-143	G1 cell cycle arrest and induction of apoptosis	Downregulation	Syn-1	Li et al. (2016)
miR-106b	G1 cell cycle arrest and inhibition of growth	Downregulation	P21/WAF1/Cip1	Prasad and Katiyar (2014)
miR-221 and miR-222	Cell proliferation	Downregulation and upregulation	PLZF, c-Kit, p27(Kip1)/CDKN1B	Felicetti et al. (2008a,b), Igoucheva and Alexeev (2009), Kanemaru et al. (2011)
miR-205	Cell proliferation	Downregulation	E2F1 and E2F5	Dar et al. (2011)
miR-155	Cell proliferation	Downregulation	SKI	Levati et al. (2011)
miR-9	Cell proliferation and migration	Downregulation	E-cadherin, NF-kB1-Snail1	Liu et al. (2012a,b)
miR-145	Suppression of cell proliferation and migration	Downregulation	c-MYC	Noguchi et al. (2012)
miR-126 and miR-126*	Melanoma progression	Downregulation	ADAM9 MMP7	Felli et al. (2013)