TABLE 4.

miRNAs in melanoma cell invasion and metastasis

miRNA	Function	Expression of miRNA	Target	Reference
miR-34b/c	Suppresses invasiveness and metastasis	Ectopic expression	MET	Migliore et al. (2008)
Let-7a	Cell Invasion	Downregulation	ITGB3	Müller and Bosserhoff (2008)
miR-182	Cell invasion and metastasis	Upregulation	FOXO3, MITF	Segura et al. (2009)
miR-200 family (miR-200c/a)	Morphologic plasticity of cells	Downregulation	MARCKS	Elson-Schwab et al. (2010)
Let-7b	Cell Invasion	Downregulation	BSG	Fu et al. (2011)
miR-30b/d	Cell invasion and metastasis	Upregulation	GALNT7	Gaziel-Sovran et al. (2011)
miR-21, miRNA 10b	Metastasis	Upregulation	BTG2	Yang et al. (2011)
miR-1908, miR-199a-5p and miR-199a-3p	Metastasis		ApoE, DNAJA4, LRP1/LRP8	Pencheva et al. (2012)
miR-200c	Cell migration and invasion	Overexpression	ZEB1	Dou et al. (2013)
miR-145	Cell migration and invasion	Overexpression	FSCN1	Dynoodt et al. (2013)
miR-30-based RNAi	Metastasis		HPSE	Liu (2013b)
miR-26a	Tumor growth and metastasis	Downregulation	Lin28B, Zcchc11	Fu et al. (2014)
miR-365	Inhibition of cell invasion and metastasis	Downregulation	NRP1	Bai et al. (2015a,b)
miR-203	Metastasis	Downregulation	BMI1	Chang et al. (2015)
miR-15a	Inhibition of growth and invasiveness	Upregulation	CDCA4	Alderman et al. (2016)
miR-194	Inhibition of cell proliferation and metastasis	Overexpression	GEF-H1	Guo et al. (2016)
miR-21, miRNA 10b	Metastasis	Upregulation	STAT3, PTEN PDCD4	Li et al. (2016), Saldanha et al. (2016a,b)
miR-339-3p	Tumor suppressor/cell invasiveness	Differential expression in melanoma cells and melanocytes	MCL-1	Weber et al. (2016)
miR-124	Inhibition of cell Invasion	Downregulation	RLIP76	Zhang et al. (2016)

BSG, basigin; HPSE, heparanase; RNAi, RNA interference.