Table 1.

Physical parameters and rate constants used in the simulation.

Parameter	Value(s)	References
Tissue nitrite	0–300 μM
Nitrite diffusion coefficient XOR concentration	410 μm2/s	Pinotti et al., 2002; Li et al., 2008; Kim-Shapiro and Gladwin, 2014
Heart	0.03 μM
Liver	0.3 μM
Reaction parameters at pH = 7.4		Maia and Moura, 2011; Maia et al., 2015
kcat	0.545 s−1
Km${\text{NO}}_2^{-}$	1918 μM
KmO2	24.3 μM
at pH = 6.3
kcat	0.581 s−1
Km${\text{NO}}_2^{-}$	251 μM
KmO2	24.3 μM