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. 2018 Jan;24(1):77–89. doi: 10.1261/rna.062927.117

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© 2018 Vincent et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 1. — Yeast ribosome biogenesis is a complex nucleolar process. Yeast rDNA, arranged in 150–200 tandem repeats on Chromosome XII, is transcribed as a polycistronic precursor pre-rRNA containing the 18S, 5.8S, and 25S mature rRNAs by RNA polymerase I (RNA Pol I). The SSU processome is required for cleaving at A₀ and A₁ in the 5′ external transcribed spacer (ETS) sequence and A₂ in the internal transcribed spacer 1 (ITS1) sequence, thereby separating SSU and LSU biogenesis. The nascent SSU is exported to the cytoplasm, where the final cleavage (at site D) occurs. At this point, the SSU is considered the mature 40S containing the 18S rRNA. The 5S rRNA is transcribed separately by RNA polymerase III (RNA Pol III).