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. 2017 Oct 26;292(50):20644–20654. doi: 10.1074/jbc.M117.818476

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© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — Stimulation of mGluR5, but not mGluR1, increases synaptic glutamate release to spinal dorsal horn neurons. A, original recording traces and cumulative plots show the effect of bath application of 20 μm DHPG on the frequency and amplitude of mEPSCs of a lamina II neuron from a naive rat. B, box-and-whisker plots show the effect of bath application of DHPG on the frequency and amplitude of mEPSCs in naive rats (n = 8 neurons, 4 rats). C, representative recording traces and cumulative plots show the effect of bath application of MPEP or LY367385 (LY) on the DHPG-induced increase in the frequency of mEPSCs of a lamina II neuron from a naive rat. D, box-and-whisker plots show the baseline and differential effect of MPEP and LY367385 on the DHPG-induced increase in the frequency of mEPSCs in naive rats (n = 10 neurons, 5 rats). *, p < 0.05 compared with the respective baseline control. Box-and-whisker plots show medians, 25^th, and 75th percentiles, and ranges.