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. 2017 Oct 26;292(50):20644–20654. doi: 10.1074/jbc.M117.818476

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© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — mGluR5 mediates paclitaxel-induced increases in synaptic glutamate release in the spinal cord. A, representative recording traces and cumulative plots show the effect of bath application of 1, 5, 10, and 20 μm MPEP on the frequency and amplitude of mEPSCs of a lamina II neuron from a vehicle-treated rat. B, representative recording traces and cumulative plots show the effect of bath application of 1, 5, 10, and 20 μm MPEP on the frequency and amplitude of mEPSCs of a lamina II neuron from a paclitaxel-treated rat. C, plots of mean data show the concentration-dependent effect of MPEP on the frequency and amplitude of mEPSCs of lamina II neurons from vehicle-treated rats (n = 8 neurons, 4 rats) and paclitaxel-treated rats (n = 9 neurons, 5 rats). Data are expressed as mean ± S.E. *, p < 0.05 compared with the respective baseline control. #, p < 0.05 compared with the baseline in the vehicle-treated group.