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Structural simulation of the interaction between Erd2 and ERS. A, the overall simulated structure of Erd2 using the I-TASSER program. B, the aromatic residues located on loop 1 (blue), loop 2 (purple), and loop 3 (red) form a characteristic subdomain facing the ER lumen. C–E, the speculated interaction between Erd2 and FEHDEL (C), WEHDEL (D), and FEKDEL (E). F, the FEHDEL polypeptide was embedded into the aromatic subdomain with the His residue inserted into the cavity of Erd2.
