Figure 3.

TRPC1 KO mice fed a HF diet and exercised have reduced insulin resistance. A–D, blood glucose (A and B), plasma insulin (C), and calculated homeostatic model assessment of insulin resistance (D) were measured from WT and TRPC1 KO mice fasted overnight after 12 weeks of diet and exercise. Data are presented as mean ± S.E. (A) or S.D. (B–D), n = 7–8. Significant (p < 0.05) effects from 3-way ANOVA are indicated by + (mouse type), × (diet), and # (exercise). A significant interaction was further analyzed using post hoc Tukey to perform pairwise comparisons. *, p < 0.05; **, p < 0.01; ****, p < 0.0001.