Table 2.

Retinal findings in study 1 after subretinal injection of AAV5-PR2.1-hCNGB3 in phenotypically normal dogs

Group	Animal ID	Eye	Vector dose (vg/eye)	Clinical ophthalmic examination	Histopathologic findings in retina
1	GS135	OD	1 × 1010	Normala	No product-related abnormalities
		OS	1 × 1010	Normala	No product-related abnormalities
2	GS137	OD	1 × 1011	Normala	No product-related abnormalities
		OS	1 × 1011	Normala	No product-related abnormalities
3	GS138	OD	1.1 × 1012	Multifocal retinitis (“black foci,” started at week 5) and focal retinal thinning (hyper-reflective areas by week 14) in bleb region	“Black foci” confirmed as subretinal aggregates of inflammatory cells with loss of photoreceptor inner and outer segments (retinal thinning)
		OS	1.1 × 1012	Same as OD	Same as OD
4	GS139	OD	1.1 × 1013	Multifocal retinitis (“black foci”) and diffuse retinal thinning (hyperreflective areas) in bleb regions started at week 3	“Black foci” confirmed as subretinal aggregates of inflammatory cells. Retinal thinning due to atrophy of outer nuclear layer.
		OS	1.1 × 1013	Same as OD	Same as OD

^aNormal except for retinotomy scar, which was seen in all eyes.

OS, left eye; OD, right eye.